Why Blood Flow?
In addition to ophthalmic conditions, changes in ocular blood flow have also been identified in Alzheimer’s disease and carotid occlusive disease (Langham, 2009; Schmetterer, 2012; Harris, 2010). Therefore, measurement of the ocular blood flow to and within the eye is unquestionably an essential factor in the diagnosis, management and therapeutic intervention in the three most common blinding conditions in the US and economically developed nations.
The majority of the scientific literature regarding the measurement of perturbations of ocular blood flow has been based on studies of the retinal circulation which represents only 10% of ocular blood flow. However, the choroidal circulation represents 85-90% of ocular blood flow. Only recently has the importance of the choroidal circulation been recognized as contributing to the early development of diabetic retinopathy (Lutty, 2013) aging macular degeneration (Bhutto, 2012) and glaucoma. This shift in focus in the science community measuring primarily the retinal circulation to a need to measure the choroidal circulation is the business opportunity for the OcuFLOW’s pulsatile ocular blood flow analyzer (POBFA).